Effects of omega-3 fatty acids on arrhythmogenic mechanisms in animal and isolated organ/cell culture studies.

s identified through the literature search were screened using eligibility criteria defined to include all English language primary experimental studies that evaluated the impact of omega-3 fatty acids on arrhythmia, intermediate mechanisms of arrhythmia, and electrogenesis. Reports published only as letters or abstracts were excluded. Articles associated with abstracts that passed these screens were retrieved and screened once more for eligibility. Studies were included if they examined the effect of omega-3 fatty acids on whole heart parameters (e.g., ventricular tachycardia, ventricular fibrillation), contractile parameters (e.g., heart rate, inotropic parameters), basoelectromechanical parameters (e.g., relative refractory period), ion pumps/movement (e.g., cytosolic calcium influx/efflux), ion currents (e.g., sodium currents), or ion channels (e.g., binding capacity).